RESUMO
Infections caused by uncommon and resistant pathogens in unusual sites have been increasingly reported in medical literature. We describe four cases of rare cytological findings and clinical impact for patients. In the first case, Aspergillus sp and Pneumocystis jirovecii were observed in the bronchoalveolar lavage of a patient with severe systemic lupus. In the second and third cases, we describe the presence of Trichomonas sp and Strongyloides sp larvae in samples of pleural and peritoneal fluid, respectively. The fourth report is about a patient with a wrist subcutaneous nodule whose synovial aspiration and cytology revealed the presence of brown septate hyphae. The early identification of the infectious agent in the cytological examination was essential for the introduction and/or re-adaptation of therapy in the four cases described. Patients in this report were immunocompromised with severe comorbidities, conditions often associated with unfavorable clinical outcomes.
Assuntos
Doenças Transmissíveis/diagnóstico , Citodiagnóstico/métodos , Animais , Líquido Ascítico/parasitologia , Aspergillus/isolamento & purificação , Líquido da Lavagem Broncoalveolar/microbiologia , Evolução Fatal , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Derrame Pleural/parasitologia , Pneumocystis carinii/isolamento & purificação , Strongyloides/isolamento & purificação , Estrongiloidíase/diagnóstico , Trichomonas/isolamento & purificação , Tricomoníase/diagnósticoRESUMO
Infections caused by uncommon and resistant pathogens in unusual sites have been increasingly reported in medical literature. We describe four cases of rare cytological findings and clinical impact for patients. In the first case, Aspergillus sp and Pneumocystis jirovecii were observed in the bronchoalveolar lavage of a patient with severe systemic lupus. In the second and third cases, we describe the presence of Trichomonas sp and Strongyloides sp larvae in samples of pleural and peritoneal fluid, respectively. The fourth report is about a patient with a wrist subcutaneous nodule whose synovial aspiration and cytology revealed the presence of brown septate hyphae. The early identification of the infectious agent in the cytological examination was essential for the introduction and/or re-adaptation of therapy in the four cases described. Patients in this report were immunocompromised with severe comorbidities, conditions often associated with unfavorable clinical outcomes.
Assuntos
Humanos , Animais , Masculino , Feminino , Pessoa de Meia-Idade , Doenças Transmissíveis/diagnóstico , Citodiagnóstico/métodos , Derrame Pleural/parasitologia , Aspergillus/isolamento & purificação , Strongyloides/isolamento & purificação , Estrongiloidíase/diagnóstico , Trichomonas/isolamento & purificação , Tricomoníase/diagnóstico , Líquido Ascítico/parasitologia , Líquido da Lavagem Broncoalveolar/microbiologia , Evolução Fatal , Pneumocystis carinii/isolamento & purificaçãoRESUMO
The cytosolic fraction of rat cerebellum possesses a factor(s) which is capable of inhibiting synaptosomal Na,K-ATPase activity, competing with [3H]ouabain binding to rat brain synaptosomes, and inducing positive inotropy in guinea pig atrial strips. These results demonstrate the existence of a ouabain-like principle in rat cerebella. The inhibitory activity of the factor was found to be partially thermolabile and diminished by a proteolytic agent, and the activity could be augmented by increasing concentrations of Mg2+, suggesting a regulatory mechanism for the endogenous digitalis-like principle.
